A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase† †Electronic supplementary information (ESI) available: Structures and characterisation for all MK compounds. Full characterisation data (NMR, HR-MS) for all SODO derivatives. See DOI: 10.1039/c6cc00095a Click here for additional data file.
نویسندگان
چکیده
Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.
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Department of Chemistry and Molecular Bio Gothenburg, Sweden. E-mail: [email protected] University of Jyvaskyla, Department of Chem FI-40014 University of Jyvaskyla, Finland Department of Chemistry and RECETOX, Brno, Czech Republic The Swedish NMR Centre, Medicinaregatan Department of Applied Chemistry, Faculty o Prilaz baruna Filipovića 28a, HR-10000 Zag † Electronic supplementary information synthe...
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