A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase† †Electronic supplementary information (ESI) available: Structures and characterisation for all MK compounds. Full characterisation data (NMR, HR-MS) for all SODO derivatives. See DOI: 10.1039/c6cc00095a Click here for additional data file.

نویسندگان

  • Liyun Zhang
  • Jun Cheng Er
  • Hao Jiang
  • Xin Li
  • Zhaofeng Luo
  • Thomas Ramezani
  • Yi Feng
  • Mui Kee Tang
  • Young-Tae Chang
  • Marc Vendrell
چکیده

Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.

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Enantioselective Narasaka–Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters† †Electronic supplementary information (ESI) available: Experimental procedures and characterisation data for all compounds are provided. CCDC 1438659 and 1438660. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc04466b Click here for additional data file. Click here for additional data file.

School of Chemistry, University of Bristol, B bris.ac.uk AstraZeneca, Alderley Park, Maccleseld, C AstraZeneca, Pepparedsleden 1, Mölndal, 4 † Electronic supplementary information ( and characterisation data for all compou 1438660. For ESI and crystallographic dat DOI: 10.1039/c6sc04466b ‡ These authors contributed equally. § Author to whom correspondence shou structures of 3b and Pd[(Sa,S)-L-...

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Department of Chemistry and Molecular Bio Gothenburg, Sweden. E-mail: [email protected] University of Jyvaskyla, Department of Chem FI-40014 University of Jyvaskyla, Finland Department of Chemistry and RECETOX, Brno, Czech Republic The Swedish NMR Centre, Medicinaregatan Department of Applied Chemistry, Faculty o Prilaz baruna Filipovića 28a, HR-10000 Zag † Electronic supplementary information synthe...

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عنوان ژورنال:

دوره 52  شماره 

صفحات  -

تاریخ انتشار 2016